Cape Girardeau, MO is currently utilizing one area code which is area code 573. Area code 573 was created from a split of area code 314 and put into service on January 7, 1996.
In addition to Cape Girardeau, MO area code 573 serves most of southeastern Missouri including the larger cities and communities of Charleston, Columbia, Farmington, Hannibal and Jefferson City, in addition to many smaller communities within the area code 573 service area.
Cape Girardeau, MO is located in Cape Girardeau County and observes the Central Time Zone.
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